InnateDB Protein
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IDBP-534270.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Insig2
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Protein Name
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insulin induced gene 2
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Synonyms
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2900053I11Rik; C730043J18Rik; Insig-2;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000124345
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InnateDB Gene
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IDBG-188177 (Insig2)
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Protein Structure
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Function |
Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR. {ECO:0000269PubMed:12242332, ECO:0000269PubMed:12624180}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in liver, testis, kidney, spleen, intestine, brain and adrenal gland. {ECO:0000269PubMed:12624180}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
29 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1920249
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InterPro |
IPR025929
Insulin-induced protein family
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PFAM |
PF07281
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q91WG1
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PhosphoSite |
PhosphoSite-
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TrEMBL |
E0CZ00
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UniProt Splice Variant |
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Entrez Gene |
72999
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UniGene |
Mm.486216
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RefSeq |
NP_001258461
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MGI ID |
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MGI Symbol |
Insig2
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OMIM |
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CCDS |
CCDS15236
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HPRD |
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IMGT |
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EMBL |
AC163333
AF527631
AK040703
AK050394
AK152076
AK154543
AK161256
AK165634
BC015288
BC023067
BC023874
BC024411
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GenPept |
AAH15288
AAH23067
AAH23874
AAH24411
AAN28332
BAC30676
BAC34233
BAE30928
BAE32667
BAE36273
BAE38307
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