InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mre11a

Summary

InnateDB Protein

IDBP-534328.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mre11a

Protein Name

meiotic recombination 11 homolog A (S. cerevisiae)

Synonyms

Mre11; Mre11b;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000116321

InnateDB Gene

IDBG-134704 (Mre11a)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 52 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	52 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004003	ATP-dependent DNA helicase activity
GO:0004519	endonuclease activity
GO:0008022	protein C-terminus binding
GO:0008408	3'-5' exonuclease activity
GO:0016787	hydrolase activity

Biological Process

GO:0000723	telomere maintenance
GO:0006284	base-excision repair
GO:0006289	nucleotide-excision repair
GO:0006302	double-strand break repair
GO:0006974	cellular response to DNA damage stimulus
GO:0007062	sister chromatid cohesion
GO:0007095	mitotic G2 DNA damage checkpoint
GO:0007129	synapsis
GO:0008283	cell proliferation
GO:0031573	intra-S DNA damage checkpoint
GO:0031954	positive regulation of protein autophosphorylation
GO:0032508	DNA duplex unwinding
GO:0032876	negative regulation of DNA endoreduplication
GO:0033674	positive regulation of kinase activity
GO:0051276	chromosome organization
GO:0090305	nucleic acid phosphodiester bond hydrolysis

Cellular Component

GO:0000781	chromosome, telomeric region
GO:0000785	chromatin
GO:0005634	nucleus
GO:0030870	Mre11 complex
GO:0035861	site of double-strand break

Protein Structure and Domains

PDB ID

MGI:1100512

InterPro

IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR029052 Metallo-dependent phosphatase-like

PFAM

PF00149

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

B2KF76

UniProt Splice Variant

Entrez Gene

17535

UniGene

Mm.413091

RefSeq

MGI ID

MGI Symbol

Mre11a

OMIM

CCDS

HPRD

IMGT

EMBL

AC136743 CT030247

GenPept