Mus musculus Gene: Mre11a | |||||||||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-134704.6 | ||||||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||
Gene Symbol | Mre11a | ||||||||||||||||||||||||||||||||||
Gene Name | meiotic recombination 11 homolog A (S. cerevisiae) | ||||||||||||||||||||||||||||||||||
Synonyms | Mre11; Mre11b | ||||||||||||||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000031928 | ||||||||||||||||||||||||||||||||||
Encoded Proteins |
meiotic recombination 11 homolog A (S. cerevisiae)
meiotic recombination 11 homolog A (S. cerevisiae)
meiotic recombination 11 homolog A (S. cerevisiae)
meiotic recombination 11 homolog A (S. cerevisiae)
meiotic recombination 11 homolog A (S. cerevisiae)
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Protein Structure | |||||||||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000020922:
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3\' to 5\' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3\' to 5\' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||||||||
Genomic Location | Chromosome 9:14784654-14837123 | ||||||||||||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||||||||||||
Band | A2 | ||||||||||||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 52 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||||||||
REACTOME |
Innate Immune System pathway
Recruitment of repair and signaling proteins to double-strand breaks pathway
MRN complex relocalizes to nuclear foci pathway
Cellular responses to stress pathway
DNA Damage/Telomere Stress Induced Senescence pathway
Double-Strand Break Repair pathway
Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks pathway
Immune System pathway
DNA Repair pathway
Cellular Senescence pathway
IRF3-mediated induction of type I IFN pathway
Cytosolic sensors of pathogen-associated DNA pathway
STING mediated induction of host immune responses pathway
Homologous Recombination Repair pathway
Homologous recombination repair of replication-independent double-strand breaks pathway
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KEGG |
Homologous recombination pathway
Non-homologous end-joining pathway
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INOH | |||||||||||||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||||||||
REACTOME |
STING mediated induction of host immune responses pathway
Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks pathway
MRN complex relocalizes to nuclear foci pathway
Recruitment of repair and signaling proteins to double-strand breaks pathway
Meiotic recombination pathway
Cellular responses to stress pathway
IRF3-mediated induction of type I IFN pathway
Homologous Recombination Repair pathway
Innate Immune System pathway
Double-Strand Break Repair pathway
Cell Cycle pathway
DNA Damage/Telomere Stress Induced Senescence pathway
Immune System pathway
Cellular Senescence pathway
Homologous recombination repair of replication-independent double-strand breaks pathway
Meiosis pathway
Cytosolic sensors of pathogen-associated DNA pathway
DNA Repair pathway
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KEGG |
Non-homologous end-joining pathway
Homologous recombination pathway
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INOH | |||||||||||||||||||||||||||||||||||
PID NCI |
Fanconi anemia pathway
BARD1 signaling events
ATM pathway
Validated transcriptional targets of deltaNp63 isoforms
Regulation of Telomerase
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Cross-References | |||||||||||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||||||||
UniGene | Mm.149071 Mm.399416 Mm.413091 | ||||||||||||||||||||||||||||||||||
RefSeq | NM_018736 XM_006510048 XM_006510049 XM_006510050 XM_006510054 | ||||||||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||||||||
CCDS | CCDS22827 | ||||||||||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||||||||||||||
MGI Symbol | |||||||||||||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||||||||||||