Mus musculus Protein: Glrx2 | |||||||||||
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Summary | |||||||||||
InnateDB Protein | IDBP-534430.3 | ||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
Gene Symbol | Glrx2 | ||||||||||
Protein Name | glutaredoxin 2 (thioltransferase) | ||||||||||
Synonyms | 1700010P22Rik; AI645710; Grx2; | ||||||||||
Species | Mus musculus | ||||||||||
Ensembl Protein | ENSMUSP00000121665 | ||||||||||
InnateDB Gene | IDBG-196991 (Glrx2) | ||||||||||
Protein Structure | |||||||||||
UniProt Annotation | |||||||||||
Function | Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release. {ECO:0000269PubMed:11397793, ECO:0000269PubMed:15347644}. | ||||||||||
Subcellular Localization | Isoform 1: Mitochondrion.Isoform 2: Nucleus. | ||||||||||
Disease Associations | |||||||||||
Tissue Specificity | Widely expressed. Highly expressed in testis, and at much lower level in kidney and brain. {ECO:0000269PubMed:12954614}. | ||||||||||
Comments | |||||||||||
Interactions | |||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||
PDB ID | MGI:1916617 | ||||||||||
InterPro |
IPR002109
Glutaredoxin IPR011899 Glutaredoxin, eukaryotic/virial IPR012336 Thioredoxin-like fold IPR014025 Glutaredoxin subgroup |
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PFAM |
PF00462
PF13098 PF13192 PF13462 PF13905 |
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PRINTS |
PR00160
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PIRSF | |||||||||||
SMART | |||||||||||
TIGRFAMs | |||||||||||
Post-translational Modifications | |||||||||||
Modification | |||||||||||
Cross-References | |||||||||||
SwissProt | Q923X4 | ||||||||||
PhosphoSite | PhosphoSite-Q923X4 | ||||||||||
TrEMBL | Q3UQ95 | ||||||||||
UniProt Splice Variant | |||||||||||
Entrez Gene | 69367 | ||||||||||
UniGene | Mm.454828 | ||||||||||
RefSeq | NP_001033682 | ||||||||||
MGI ID | |||||||||||
MGI Symbol | Glrx2 | ||||||||||
OMIM | |||||||||||
CCDS | CCDS15344 | ||||||||||
HPRD | |||||||||||
IMGT | |||||||||||
EMBL | AF276918 AF380337 AK005853 AK142654 | ||||||||||
GenPept | AAF86465 AAK85319 BAB24276 BAE25147 | ||||||||||