InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dohh

Summary

InnateDB Protein

IDBP-534526.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dohh

Protein Name

deoxyhypusine hydroxylase/monooxygenase

Synonyms

1110033C18Rik; AI585913; AL022869; Hlrc1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000116074

InnateDB Gene

IDBG-271119 (Dohh)

Protein Structure

UniProt Annotation

Function

Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)- L-lysine intermediate to form hypusine, an essential post- translational modification only found in mature eIF-5A factor. {ECO:0000255HAMAP-Rule:MF_03101}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0019135	deoxyhypusine monooxygenase activity
GO:0046872	metal ion binding

Biological Process

GO:0008612	peptidyl-lysine modification to peptidyl-hypusine
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005575

cellular_component

Protein Structure and Domains

PDB ID

MGI:1915964

InterPro

IPR004155 PBS lyase HEAT-like repeat
IPR016024 Armadillo-type fold

PFAM

PF03130

PRINTS

PIRSF

SMART

SM00567

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99LN9

PhosphoSite

PhosphoSite-

TrEMBL

D3Z7J7

UniProt Splice Variant

Entrez Gene

102115

UniGene

Mm.485349

RefSeq

XP_006514419

MGI ID

MGI Symbol

Dohh

OMIM

CCDS

HPRD

IMGT

EMBL

AC155937 AK004052 AK080664 BC002295

GenPept

AAH02295 BAC25064 BAC37972