InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tra2b

Summary

InnateDB Protein

IDBP-534539.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tra2b

Protein Name

transformer 2 beta homolog (Drosophila)

Synonyms

5730405G21Rik; D16Ertd266e; Sfrs10; SIG-41; Silg41; TRA2beta;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000124846

InnateDB Gene

IDBG-148073 (Tra2b)

Protein Structure

UniProt Annotation

Function

Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. Highly expressed in uterus and brain. {ECO:0000269PubMed:8674539}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 58 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	58 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000381	regulation of alternative mRNA splicing, via spliceosome
GO:0000398	mRNA splicing, via spliceosome
GO:0048026	positive regulation of mRNA splicing, via spliceosome