Version 5.4
Homo sapiens Protein: COMMD1
Summary
InnateDB Protein IDBP-53459.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COMMD1
Protein Name copper metabolism (Murr1) domain containing 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000308236
InnateDB Gene IDBG-53457 (COMMD1)
Protein Structure
UniProt Annotation
Function Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes. {ECO:0000269PubMed:14685266, ECO:0000269PubMed:15799966, ECO:0000269PubMed:16573520, ECO:0000269PubMed:17183367, ECO:0000269PubMed:17309234, ECO:0000269PubMed:20048074, ECO:0000269PubMed:20595380}.
Subcellular Localization Nucleus. Cytoplasm. Note=Shuttles between nucleus and cytosol. Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins.
Disease Associations
Tissue Specificity Ubiquitous. Highest expression in the liver, with lower expression in brain, lung, placenta, pancreas, small intestine, heart, skeletal muscle, kidney and placenta. {ECO:0000269PubMed:11809725, ECO:0000269PubMed:15799966, ECO:0000269PubMed:16573520}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
Experimentally validated
Total 73 [view]
Protein-Protein 73 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0031398 positive regulation of protein ubiquitination
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0055070 copper ion homeostasis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0031462 Cul2-RING ubiquitin ligase complex
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR009886 HCaRG
PFAM PF07258
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N668
PhosphoSite PhosphoSite-Q8N668
TrEMBL Q53SJ8
UniProt Splice Variant
Entrez Gene 150684
UniGene
RefSeq NP_689729
HUGO HGNC:23024
OMIM 607238
CCDS CCDS1869
HPRD 06253
IMGT
EMBL AB178811 AC018462 AC107081 AC116652 BC009266 BC022046
GenPept AAH09266 AAH22046 AAX93080 AAY24054 AAY24141 BAD18972

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca