InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ddit3

Summary

InnateDB Protein

IDBP-534667.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ddit3

Protein Name

DNA-damage inducible transcript 3

Synonyms

chop; CHOP-10; CHOP10; gadd153;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000118339

InnateDB Gene

IDBG-194880 (Ddit3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 57 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	57 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0008134	transcription factor binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006983	ER overload response
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0032757	positive regulation of interleukin-8 production
GO:0042789	mRNA transcription from RNA polymerase II promoter
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045454	cell redox homeostasis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:2000016	negative regulation of determination of dorsal identity

Cellular Component

GO:0005634	nucleus
GO:0005770	late endosome

Protein Structure and Domains

PDB ID

MGI:109247

InterPro

IPR004827 Basic-leucine zipper domain
IPR016670 DNA damage-inducible transcript 3

PFAM

PF00170
PF07716

PRINTS

PIRSF

PIRSF016571

SMART

SM00338

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

D3YX14

UniProt Splice Variant

Entrez Gene

13198

UniGene

Mm.110220

RefSeq

MGI ID

MGI Symbol

Ddit3

OMIM

CCDS

HPRD

IMGT

EMBL

AC144852

GenPept