InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ddit3

Summary

InnateDB Gene

IDBG-194880.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ddit3

Gene Name

DNA-damage inducible transcript 3

Synonyms

chop; CHOP-10; CHOP10; gadd153

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025408

Encoded Proteins

IDBP-194882

DNA-damage inducible transcript 3

IDBP-534667

DNA-damage inducible transcript 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 20876114

[Homo sapiens] DDIT3 (CHOP) is an endoplasmic reticulum (ER) stress-induced transcription factor that targets the IL23 gene and this binding is enhanced in the context of both ER stress and Toll-like receptor (TLR) stimulation.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175197:
This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:127290774-127296288

Strand

Forward strand

Band

Transcripts

ENSMUST00000026475	ENSMUSP00000026475
ENSMUST00000139091	ENSMUSP00000118339
ENSMUST00000134686

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 57 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	57 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001955	blood vessel maturation
GO:0006355	regulation of transcription, DNA-templated
GO:0006915	apoptotic process
GO:0006983	ER overload response
GO:0006986	response to unfolded protein
GO:0007050	cell cycle arrest
GO:0016055	Wnt signaling pathway
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0032757	positive regulation of interleukin-8 production
GO:0034976	response to endoplasmic reticulum stress
GO:0042594	response to starvation
GO:0042789	mRNA transcription from RNA polymerase II promoter
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043525	positive regulation of neuron apoptotic process
GO:0044324	regulation of transcription involved in anterior/posterior axis specification
GO:0045454	cell redox homeostasis
GO:0045662	negative regulation of myoblast differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051209	release of sequestered calcium ion into cytosol
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:2000016	negative regulation of determination of dorsal identity