InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ins2

Summary

InnateDB Protein

IDBP-534750.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ins2

Protein Name

insulin II

Synonyms

AA986540; Ins-2; InsII; Mody; Mody4; proinsulin;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000115147

InnateDB Gene

IDBG-212636 (Ins2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000187	activation of MAPK activity
GO:0006006	glucose metabolic process
GO:0006983	ER overload response
GO:0007520	myoblast fusion
GO:0008286	insulin receptor signaling pathway
GO:0010468	regulation of gene expression
GO:0014902	myotube differentiation
GO:0015758	glucose transport
GO:0016042	lipid catabolic process
GO:0042325	regulation of phosphorylation
GO:0043393	regulation of protein binding
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
GO:0060070	canonical Wnt signaling pathway
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

Cellular Component

GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005732	small nucleolar ribonucleoprotein complex
GO:0005737	cytoplasm
GO:0030141	secretory granule

Protein Structure and Domains

PDB ID

MGI:96573

InterPro

IPR004825 Insulin
IPR016179 Insulin-like

PFAM

PF00049

PRINTS

PR00277

PIRSF

SMART

SM00078

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

D3YWU5

UniProt Splice Variant

Entrez Gene

16334

UniGene

RefSeq

MGI ID

MGI Symbol

Ins2

OMIM

CCDS

HPRD

IMGT

EMBL

AC013548

GenPept