InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lcp1

Summary

InnateDB Protein

IDBP-534781.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lcp1

Protein Name

lymphocyte cytosolic protein 1

Synonyms

AW536232; D14Ertd310e; LCP-1; Pls2; pp65;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000117137

InnateDB Gene

IDBG-180662 (Lcp1)

Protein Structure

UniProt Annotation

Function

Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000269PubMed:14756805}. Cell projection {ECO:0000250}. Cell junction {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000269PubMed:14756805}; Peripheral membrane protein {ECO:0000269PubMed:14756805}; Cytoplasmic side {ECO:0000269PubMed:14756805}. Note=Relocalizes to the immunological synapse between peripheral blood T-lymphocytes and antibody-presenting cells in response to costimulation through TCR/CD3 and CD2 or CD28. Relocalizes to actin-rich cell projections upon serine phosphorylation (By similarity). Associated with the actin cytoskeleton at membrane ruffles. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0051015	actin filament binding

Biological Process

GO:0002286	T cell activation involved in immune response
GO:0031100	organ regeneration
GO:0033157	regulation of intracellular protein transport
GO:0051017	actin filament bundle assembly