InnateDB Protein
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IDBP-534801.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Rreb1
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Protein Name
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ras responsive element binding protein 1
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Synonyms
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1110037N09Rik; AA414966; B930013M22Rik;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000115599
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InnateDB Gene
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IDBG-145333 (Rreb1)
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Protein Structure
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Function |
Transcription factor that binds specifically to the RAS- responsive elements (RRE) of gene promoters. May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression. Represses the angiotensinogen gene. Negatively regulates the transcriptional activity of AR. Potentiates the transcriptional activity of NEUROD1 (By similarity). Binds specifically to the allelic variant of the CDKN2A promoter present in Balb/c mice, which leads to a down-regulation of CDKN2A expression in this strain, and, as a consequence, to an elevated susceptibility to pristane-induced tumors. {ECO:0000250, ECO:0000269PubMed:12700664}.
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Subcellular Localization |
Nucleus speckle {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in splenic B-cells. {ECO:0000269PubMed:12700664}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
0
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
9 [view]
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Molecular Function |
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Biological Process |
GO:0006351
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transcription, DNA-templated
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GO:0045892
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negative regulation of transcription, DNA-templated
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Cellular Component |
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PDB ID |
MGI:2443664
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InterPro |
IPR007087
Zinc finger, C2H2
IPR015880
Zinc finger, C2H2-like
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PFAM |
PF00096
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PRINTS |
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PIRSF |
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SMART |
SM00355
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TIGRFAMs |
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Modification |
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SwissProt |
Q3UH06
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PhosphoSite |
PhosphoSite-Q3UH06
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TrEMBL |
B8JJE4
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UniProt Splice Variant |
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Entrez Gene |
68750
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UniGene |
Mm.482689
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RefSeq |
XP_006516812
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MGI ID |
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MGI Symbol |
Rreb1
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OMIM |
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CCDS |
CCDS49238
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HPRD |
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IMGT |
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EMBL |
AC022682
AK147653
AK154980
AK171375
AY946044
BC080680
CT010477
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GenPept |
AAH80680
AAX83010
BAE28051
BAE32969
BAE42417
CAX15920
CAX15921
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