InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tdg

Summary

InnateDB Protein

IDBP-534808.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tdg

Protein Name

thymine DNA glycosylase

Synonyms

E130317C12Rik; JZA-3; Jza1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000116707

InnateDB Gene

IDBG-179611 (Tdg)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	7 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0003690	double-stranded DNA binding
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0008263	pyrimidine-specific mismatch base pair DNA N-glycosylase activity
GO:0032183	SUMO binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006284	base-excision repair
GO:0006366	transcription from RNA polymerase II promoter
GO:0032091	negative regulation of protein binding
GO:0035562	negative regulation of chromatin binding

Cellular Component

GO:0005634	nucleus
GO:0016605	PML body

Protein Structure and Domains

PDB ID

MGI:108247

InterPro

IPR005122 Uracil-DNA glycosylase-like

PFAM

PF03167

PRINTS

PIRSF

SMART

SM00986

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

D3Z417

UniProt Splice Variant

Entrez Gene

545124

UniGene

Mm.472997

RefSeq

MGI ID

MGI Symbol

Tdg

OMIM

CCDS

HPRD

IMGT

EMBL

AC152980

GenPept