InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tdg

Summary

InnateDB Gene

IDBG-179611.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tdg

Gene Name

thymine DNA glycosylase

Synonyms

E130317C12Rik; JZA-3; Jza1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000034674

Encoded Proteins

IDBP-179613

thymine DNA glycosylase

IDBP-535195

thymine DNA glycosylase

IDBP-534808

thymine DNA glycosylase

IDBP-711815

IDBP-712735

IDBP-711967

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139372:
The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:82629828-82650799

Strand

Forward strand

Band

Transcripts

ENSMUST00000092266	ENSMUSP00000089917
ENSMUST00000151390	ENSMUSP00000121000
ENSMUST00000133227
ENSMUST00000145370	ENSMUSP00000116707
ENSMUST00000148790
ENSMUST00000135652
ENSMUST00000125970
ENSMUST00000142658
ENSMUST00000176326	ENSMUSP00000135009
ENSMUST00000177353	ENSMUSP00000135621
ENSMUST00000176195	ENSMUSP00000135883

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	7 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0003690	double-stranded DNA binding
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008263	pyrimidine-specific mismatch base pair DNA N-glycosylase activity
GO:0016798	hydrolase activity, acting on glycosyl bonds
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0019104	DNA N-glycosylase activity
GO:0019904	protein domain specific binding
GO:0030983	mismatched DNA binding
GO:0032183	SUMO binding
GO:0042803	protein homodimerization activity
GO:0043566	structure-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006281	DNA repair
GO:0006284	base-excision repair
GO:0006298	mismatch repair
GO:0006366	transcription from RNA polymerase II promoter
GO:0009790	embryo development
GO:0016568	chromatin modification
GO:0032091	negative regulation of protein binding
GO:0035562	negative regulation of chromatin binding
GO:0040029	regulation of gene expression, epigenetic
GO:0080111	DNA demethylation