InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Casp4

Summary

InnateDB Protein

IDBP-534810.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Casp4

Protein Name

caspase 4, apoptosis-related cysteine peptidase

Synonyms

Casp11; Caspl; ich-3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000124249

InnateDB Gene

IDBG-131657 (Casp4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity

Biological Process

GO:0006508	proteolysis
GO:0035234	ectopic germ cell programmed cell death
GO:0042981	regulation of apoptotic process
GO:0050718	positive regulation of interleukin-1 beta secretion
GO:0050727	regulation of inflammatory response
GO:0070269	pyroptosis
GO:0097194	execution phase of apoptosis

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0072557	IPAF inflammasome complex
GO:0072559	NLRP3 inflammasome complex
GO:0097169	AIM2 inflammasome complex

Protein Structure and Domains

PDB ID

MGI:107700

InterPro

IPR001315 CARD domain
IPR011029 Death-like domain

PFAM

PF00619

PRINTS

PIRSF

SMART

SM00114

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

C6L648

UniProt Splice Variant

Entrez Gene

12363

UniGene

Mm.1569

RefSeq

MGI ID

MGI Symbol

Casp4

OMIM

CCDS

HPRD

IMGT

EMBL

AB480706 AC141637

GenPept

BAH96541