InnateDB Protein
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IDBP-53500.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CCDC53
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Protein Name
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coiled-coil domain containing 53
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000240079
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InnateDB Gene
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IDBG-53498 (CCDC53)
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Protein Structure
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Function |
Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting. {ECO:0000269PubMed:19922875}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
25
[view]
|
Protein-Protein |
24
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR019309
WASH complex, subunit CCDC53
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PFAM |
PF10152
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y3C0
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PhosphoSite |
PhosphoSite-Q9Y3C0
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TrEMBL |
F5H0A7
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UniProt Splice Variant |
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Entrez Gene |
51019
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UniGene |
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RefSeq |
NP_057137
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HUGO |
HGNC:24256
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OMIM |
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CCDS |
CCDS44959
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HPRD |
13031
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IMGT |
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EMBL |
AC079907
AF151874
AF155655
AK223339
AK314970
BC010889
CH471054
CR457171
FJ695207
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GenPept |
AAD34111
AAF67012
AAH10889
BAD97059
BAG37471
CAG33452
EAW97687
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