Version 5.4
Homo sapiens Protein: ARSI
Summary
InnateDB Protein IDBP-53503.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARSI
Protein Name arylsulfatase family, member I
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000333395
InnateDB Gene IDBG-53501 (ARSI)
Protein Structure
UniProt Annotation
Function Displays arylsulfatase activity at neutral pH, when co- expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts. {ECO:0000269PubMed:16500042, ECO:0000269PubMed:19262745}.
Subcellular Localization Secreted {ECO:0000269PubMed:19262745}. Endoplasmic reticulum {ECO:0000269PubMed:19262745}. Note=Localized in the intracellular granular structures.
Disease Associations
Tissue Specificity Expressed in placenta, in embryonic stem cells, fetal eyes and lens. {ECO:0000269PubMed:16500042, ECO:0000269PubMed:19262745}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004065 arylsulfatase activity
GO:0008484 sulfuric ester hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006665 sphingolipid metabolic process
GO:0006687 glycosphingolipid metabolic process
GO:0008152 metabolic process
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005788 endoplasmic reticulum lumen
Protein Structure and Domains
PDB ID
InterPro IPR000917 Sulfatase
IPR017850 Alkaline-phosphatase-like, core domain
PFAM PF00884
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5FYB1
PhosphoSite PhosphoSite-Q5FYB1
TrEMBL D6RDH0
UniProt Splice Variant
Entrez Gene 340075
UniGene Hs.591252
RefSeq NP_001012301
HUGO HGNC:32521
OMIM 610009
CCDS CCDS34275
HPRD 16510
IMGT
EMBL AB448735 AC011372 AK122641 AY875937 BC129995 BC129996
GenPept AAI29996 AAI29997 AAW66665 BAG53634 BAH11166

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca