InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hrh1

Summary

InnateDB Protein

IDBP-535032.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hrh1

Protein Name

histamine receptor H1

Synonyms

Bphs; H1R; HH1R; Hir;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000124460

InnateDB Gene

IDBG-178946 (Hrh1)

Protein Structure

UniProt Annotation

Function

In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. Involved in circadian rhythm of locomotor activity and exploratory behavior. Also involved in responsiveness to pertussis toxin through its control of susceptibility to histamine hypersensitivity and enhancement of antigen-specific delayed-type hypersensitivity responses. {ECO:0000269PubMed:12595443, ECO:0000269PubMed:8917588}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004969	histamine receptor activity
GO:0015085	calcium ion transmembrane transporter activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007613	memory
GO:0008542	visual learning
GO:0043114	regulation of vascular permeability
GO:0045907	positive regulation of vasoconstriction
GO:0048167	regulation of synaptic plasticity
GO:0048245	eosinophil chemotaxis
GO:0048511	rhythmic process
GO:0070509	calcium ion import
GO:0071420	cellular response to histamine
GO:0071421	manganese ion transmembrane transport

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:107619

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000921 Histamine H1 receptor
IPR000995 Muscarinic acetylcholine receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00530
PR00243

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P70174