InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Chrna4

Summary

InnateDB Protein

IDBP-535094.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Chrna4

Protein Name

cholinergic receptor, nicotinic, alpha polypeptide 4

Synonyms

Acra-4; Acra4; EBN1; ENFL1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000123043

InnateDB Gene

IDBG-213951 (Chrna4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004889	acetylcholine-activated cation-selective channel activity
GO:0005216	ion channel activity
GO:0005230	extracellular ligand-gated ion channel activity
GO:0005515	protein binding

Biological Process

GO:0001508	action potential
GO:0006810	transport
GO:0006816	calcium ion transport
GO:0007271	synaptic transmission, cholinergic
GO:0007585	respiratory gaseous exchange
GO:0007626	locomotory behavior
GO:0014059	regulation of dopamine secretion
GO:0019233	sensory perception of pain
GO:0034220	ion transmembrane transport
GO:0035094	response to nicotine
GO:0035095	behavioral response to nicotine
GO:0035640	exploration behavior
GO:0042113	B cell activation
GO:0042391	regulation of membrane potential
GO:0050877	neurological system process
GO:0051899	membrane depolarization
GO:0060080	regulation of inhibitory postsynaptic membrane potential

Cellular Component

GO:0005886	plasma membrane
GO:0005892	acetylcholine-gated channel complex
GO:0009897	external side of plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:87888

InterPro

IPR006202 Neurotransmitter-gated ion-channel ligand-binding

PFAM

PF02931

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

B7ZBV1

UniProt Splice Variant

Entrez Gene

11438

UniGene

Mm.252369

RefSeq

MGI ID

MGI Symbol

Chrna4

OMIM

CCDS

HPRD

IMGT

EMBL

AL450341

GenPept