InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: B230120H23Rik

Summary

InnateDB Protein

IDBP-535127.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

B230120H23Rik

Protein Name

RIKEN cDNA B230120H23 gene

Synonyms

AV006891; B230120H23Rik; MLTK; MLTKalpha; MLTKbeta;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000118983

InnateDB Gene

IDBG-179557 (B230120H23Rik)

Protein Structure

UniProt Annotation

Function

Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Pro- apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2. Isoform 1, but not isoform 2, phosphorylates histone H3 at 'Ser-28'. {ECO:0000269PubMed:11042189}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11042189}. Nucleus {ECO:0000269PubMed:11042189}. Note=Appears to shuttle between nucleus and cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004709	MAP kinase kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000075	cell cycle checkpoint
GO:0000077	DNA damage checkpoint
GO:0000186	activation of MAPKK activity
GO:0006468	protein phosphorylation
GO:0007010	cytoskeleton organization
GO:0007050	cell cycle arrest
GO:0007257	activation of JUN kinase activity
GO:0009314	response to radiation
GO:0035556	intracellular signal transduction
GO:0043065	positive regulation of apoptotic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:2443258

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt