InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UBTF

Summary

InnateDB Protein

IDBP-53515.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBTF

Protein Name

upstream binding transcription factor, RNA polymerase I

Synonyms

NOR-90; UBF; UBF-1; UBF1; UBF2;

Species

Homo sapiens

Ensembl Protein

ENSP00000302640

InnateDB Gene

IDBG-53511 (UBTF)

Protein Structure

UniProt Annotation

Function

Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element. {ECO:0000269PubMed:7982918}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 63 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	63 [view]
Protein-Protein	62 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005488	binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000183	chromatin silencing at rDNA
GO:0006356	regulation of transcription from RNA polymerase I promoter
GO:0006360	transcription from RNA polymerase I promoter
GO:0006361	transcription initiation from RNA polymerase I promoter
GO:0006362	transcription elongation from RNA polymerase I promoter
GO:0006363	termination of RNA polymerase I transcription
GO:0010467	gene expression
GO:0045943	positive regulation of transcription from RNA polymerase I promoter