InnateDB Protein
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IDBP-535173.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Spn
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Protein Name
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sialophorin
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Synonyms
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A630014B01Rik; Cd43; Galgp; Ly-48; Ly48;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000122787
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InnateDB Gene
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IDBG-210057 (Spn)
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Protein Structure
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Function |
One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter-receptor for SN/Siglec-1. During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response. {ECO:0000269PubMed:11728336}.
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Subcellular Localization |
Membrane; Single-pass type I membrane protein.
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Disease Associations |
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Tissue Specificity |
Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:98384
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P15702
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PhosphoSite |
PhosphoSite-P15702
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TrEMBL |
Q544C5
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UniProt Splice Variant |
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Entrez Gene |
20737
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UniGene |
Mm.283714
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RefSeq |
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MGI ID |
2EMS
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MGI Symbol |
Spn
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OMIM |
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CCDS |
CCDS21858
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HPRD |
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IMGT |
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EMBL |
AK041480
AK134098
BC100738
BC100739
BC100740
BC100741
CH466531
M30693
S70677
X17018
X52609
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GenPept |
AAA39457
AAB30765
AAI00739
AAI00740
AAI00741
AAI00742
BAC30957
BAE22012
CAA34884
CAA36840
EDL17502
EDL17503
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