InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Spn

Summary

InnateDB Gene

IDBG-210057.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Spn

Gene Name

sialophorin

Synonyms

A630014B01Rik; Cd43; Galgp; Ly-48; Ly48

Species

Mus musculus

Ensembl Gene

ENSMUSG00000051457

Encoded Proteins

IDBP-210061

sialophorin

IDBP-535173

sialophorin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197471:
The protein encoded by this gene is a major sialoglycoprotein found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It may be part of a physiologic ligand-receptor complex involved in T-cell activation. During T-cell activation, this protein is actively removed from the T-cell-APC (antigen-presenting cell) contact site, suggesting a negative regulatory role in adaptive immune response. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:127132232-127137823

Strand

Reverse strand

Band

Transcripts

ENSMUST00000049931	ENSMUSP00000049534
ENSMUST00000143713	ENSMUSP00000122787

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001562	response to protozoan
GO:0001808	negative regulation of type IV hypersensitivity
GO:0001934	positive regulation of protein phosphorylation
GO:0007162	negative regulation of cell adhesion
GO:0007166	cell surface receptor signaling pathway
GO:0031295	T cell costimulation
GO:0042102	positive regulation of T cell proliferation
GO:0042130	negative regulation of T cell proliferation
GO:0042535	positive regulation of tumor necrosis factor biosynthetic process
GO:0042742	defense response to bacterium
GO:0045060	negative thymic T cell selection
GO:0050688	regulation of defense response to virus
GO:0050776	regulation of immune response
GO:0050868	negative regulation of T cell activation
GO:0097190	apoptotic signaling pathway

Cellular Component

GO:0001931	uropod
GO:0005604	basement membrane
GO:0005615	extracellular space
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000197471

View Gene Order

ENSBTAG00000026326

Not yet available

Pathways

NETPATH

REACTOME

REACT_224553

Hemostasis pathway

REACT_225233

Cell surface interactions at the vascular wall pathway

REACT_211508

Basigin interactions pathway

KEGG

mmu04514

Cell adhesion molecules (CAMs) pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_12560

Basigin interactions pathway

REACT_12051

Cell surface interactions at the vascular wall pathway

REACT_604

Hemostasis pathway

KEGG

hsa04514

Cell adhesion molecules (CAMs) pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.283714

RefSeq

NM_001037810 NM_009259 XM_006507522

OMIM

CCDS

CCDS21858

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas