InnateDB Protein
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IDBP-535176.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Zfat
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Protein Name
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zinc finger and AT hook domain containing
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000125257
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InnateDB Gene
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IDBG-147216 (Zfat)
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Protein Structure
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Function |
May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated. {ECO:0000269PubMed:18329245}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:18329245}. Cytoplasm, cytosol {ECO:0000269PubMed:18329245}.
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Disease Associations |
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Tissue Specificity |
Detected in spleen and thymus but not in liver, muscle, heart, kidney, brain, bone marrow or pancreas. Expressed in CD19+, CD4+ and CD8+ lymphocytes but not in CD11b+ lymphocytes or peritoneal macrophages (at protein level). {ECO:0000269PubMed:18329245}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
0
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0001077
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RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
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GO:0003677
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DNA binding
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GO:0046872
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metal ion binding
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2681865
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InterPro |
IPR007087
Zinc finger, C2H2
IPR015880
Zinc finger, C2H2-like
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PFAM |
PF00096
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PRINTS |
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PIRSF |
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SMART |
SM00355
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TIGRFAMs |
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Modification |
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SwissProt |
Q7TS63
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PhosphoSite |
PhosphoSite-Q7TS63
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
380993
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UniGene |
Mm.309526
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RefSeq |
NP_001139360
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MGI ID |
2ELX
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MGI Symbol |
Zfat
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OMIM |
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CCDS |
CCDS49623
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HPRD |
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IMGT |
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EMBL |
BC053930
EU221277
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GenPept |
AAH53930
ABY67968
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