InnateDB Protein
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IDBP-535184.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Fgd4
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Protein Name
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FYVE, RhoGEF and PH domain containing 4
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000125435
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InnateDB Gene
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IDBG-137062 (Fgd4)
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Protein Structure
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Function |
Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates MAPK8 (By similarity). Plays a role in regulating the actin cytoskeleton and cell shape. Promotes the formation of lamellipodia. {ECO:0000250, ECO:0000269PubMed:10871857, ECO:0000269PubMed:11527409}.
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Subcellular Localization |
Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Note=Concentrated in filopodia and poorly detected at lamellipodia. Binds along the sides of actin fibers (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Detected in thymus, lung, heart, skeletal muscle, small intestine, liver, kidney, spleen and testis. Expressed in all parts of the brain and in the spinal cord at embryonic, postnatal, and adult stages. Levels of expression are lower in postnatal and adult tissues than in embryonic tissues. {ECO:0000269PubMed:11527409, ECO:0000269PubMed:17564959}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
0
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2183747
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InterPro |
IPR000219
Dbl homology (DH) domain
IPR001849
Pleckstrin homology domain
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PFAM |
PF00621
PF00169
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PRINTS |
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PIRSF |
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SMART |
SM00325
SM00233
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TIGRFAMs |
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Modification |
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SwissProt |
Q91ZT5
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PhosphoSite |
PhosphoSite-Q91ZT5
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TrEMBL |
E0CZ69
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UniProt Splice Variant |
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Entrez Gene |
224014
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UniGene |
Mm.405784
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RefSeq |
NP_631980
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MGI ID |
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MGI Symbol |
Fgd4
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OMIM |
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CCDS |
CCDS49773
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HPRD |
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IMGT |
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EMBL |
AC169505
AF402611
AF402612
AF402613
AK034504
AK054242
AK149626
BC129902
BC129903
CT476831
CT573014
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GenPept |
AAI29903
AAI29904
AAL05631
AAL05632
AAL05633
BAC28733
BAC35703
BAE28995
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