Version 5.4
Mus musculus Protein: Apaf1
Summary
InnateDB Protein IDBP-535328.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Apaf1
Protein Name apoptotic peptidase activating factor 1
Synonyms 6230400I06Rik; Apaf-1; Apaf1l; fog; mKIAA0413;
Species Mus musculus
Ensembl Protein ENSMUSP00000124422
InnateDB Gene IDBG-185032 (Apaf1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0042802 identical protein binding
GO:0043531 ADP binding
Biological Process
GO:0001843 neural tube closure
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007275 multicellular organismal development
GO:0007420 brain development
GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0030900 forebrain development
GO:0042981 regulation of apoptotic process
GO:0051402 neuron apoptotic process
GO:1902510 regulation of apoptotic DNA fragmentation
GO:2001235 positive regulation of apoptotic signaling pathway
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005829 cytosol
GO:0043293 apoptosome
Protein Structure and Domains
PDB ID MGI:1306796
InterPro IPR001315 CARD domain
IPR002182 NB-ARC
IPR011029 Death-like domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00619
PF00931
PRINTS
PIRSF
SMART SM00114
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q80VR5
UniProt Splice Variant
Entrez Gene 11783
UniGene Mm.473243
RefSeq
MGI ID
MGI Symbol Apaf1
OMIM
CCDS
HPRD
IMGT
EMBL AC138719 AC140410 AJ970309 BC045144
GenPept AAH45144 CAI94751

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca