Version 5.4
Mus musculus Protein: Xrcc4
Summary
InnateDB Protein IDBP-535404.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Xrcc4
Protein Name X-ray repair complementing defective repair in Chinese hamster cells 4
Synonyms 2310057B22Rik; AW413319; AW545101;
Species Mus musculus
Ensembl Protein ENSMUSP00000125486
InnateDB Gene IDBG-171005 (Xrcc4)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
Predicted by orthology
Total 32 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0008022 protein C-terminus binding
Biological Process
GO:0001701 in utero embryonic development
GO:0002328 pro-B cell differentiation
GO:0006266 DNA ligation
GO:0006302 double-strand break repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006310 DNA recombination
GO:0007417 central nervous system development
GO:0010165 response to X-ray
GO:0010212 response to ionizing radiation
GO:0010332 response to gamma radiation
GO:0033077 T cell differentiation in thymus
GO:0033151 V(D)J recombination
GO:0033152 immunoglobulin V(D)J recombination
GO:0043524 negative regulation of neuron apoptotic process
GO:0045190 isotype switching
GO:0048146 positive regulation of fibroblast proliferation
GO:0050769 positive regulation of neurogenesis
GO:0051103 DNA ligation involved in DNA repair
GO:0051351 positive regulation of ligase activity
GO:0071285 cellular response to lithium ion
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex
GO:0032807 DNA ligase IV complex
Protein Structure and Domains
PDB ID MGI:1333799
InterPro IPR009089 DNA double-strand break repair and VJ recombination XRCC4, N-terminal
IPR010585 DNA repair protein XRCC4
PFAM PF06632
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E0CZC8
UniProt Splice Variant
Entrez Gene 108138
UniGene
RefSeq
MGI ID
MGI Symbol Xrcc4
OMIM
CCDS
HPRD
IMGT
EMBL AC154535 AC155248
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca