InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Vamp4

Summary

InnateDB Protein

IDBP-535483.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vamp4

Protein Name

vesicle-associated membrane protein 4

Synonyms

D1Ertd147e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000115133

InnateDB Gene

IDBG-201827 (Vamp4)

Protein Structure

UniProt Annotation

Function

Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule (By similarity). {ECO:0000250}.

Subcellular Localization

Golgi apparatus, trans-Golgi network membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. Note=Associated with trans Golgi network (TGN) and newly formed immature secretory granules (ISG). Not found on the mature secretory organelles (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000149	SNARE binding
GO:0005484	SNAP receptor activity

Biological Process

GO:0006887	exocytosis
GO:0006897	endocytosis
GO:0006906	vesicle fusion
GO:0016192	vesicle-mediated transport
GO:0042996	regulation of Golgi to plasma membrane protein transport
GO:0043001	Golgi to plasma membrane protein transport