Version 5.4
Mus musculus Protein: Irf8
Summary
InnateDB Protein IDBP-535532.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Irf8
Protein Name interferon regulatory factor 8
Synonyms AI893568; ICSBP; Icsbp1; IRF-8; Myls;
Species Mus musculus
Ensembl Protein ENSMUSP00000125443
InnateDB Gene IDBG-196509 (Irf8)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 337 experimentally validated interaction(s) in this database.
They are also associated with 70 interaction(s) predicted by orthology.
Experimentally validated
Total 337 [view]
Protein-Protein 23 [view]
Protein-DNA 314 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 70 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000975 regulatory region DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006909 phagocytosis
GO:0006955 immune response
GO:0009617 response to bacterium
GO:0030099 myeloid cell differentiation
GO:0032729 positive regulation of interferon-gamma production
GO:0032735 positive regulation of interleukin-12 production
GO:0042742 defense response to bacterium
GO:0042832 defense response to protozoan
GO:0044130 negative regulation of growth of symbiont in host
GO:0045087 innate immune response (InnateDB)
GO:0045893 positive regulation of transcription, DNA-templated
GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter
GO:0071222 cellular response to lipopolysaccharide
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:96395
InterPro IPR001346 Interferon regulatory factor DNA-binding domain
IPR008984 SMAD/FHA domain
IPR019471 Interferon regulatory factor-3
PFAM PF00605
PF10401
PRINTS PR00267
PIRSF
SMART SM00348
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E0CZE4
UniProt Splice Variant
Entrez Gene 15900
UniGene Mm.334861
RefSeq
MGI ID
MGI Symbol Irf8
OMIM
CCDS
HPRD
IMGT
EMBL AC114819
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca