InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cxcr4

Summary

InnateDB Protein

IDBP-535562.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cxcr4

Protein Name

chemokine (C-X-C motif) receptor 4

Synonyms

b2b220Clo; CD184; Cmkar4; LESTR; PB-CKR; PBSF/SDF-1; Sdf1r;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000120153

InnateDB Gene

IDBG-189999 (Cxcr4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	1 [view]
Protein-DNA	4 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	54 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0016494	C-X-C chemokine receptor activity
GO:0019955	cytokine binding

Biological Process

GO:0001569	patterning of blood vessels
GO:0001667	ameboidal cell migration
GO:0001764	neuron migration
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007281	germ cell development
GO:0007420	brain development
GO:0008045	motor neuron axon guidance
GO:0008354	germ cell migration
GO:0019722	calcium-mediated signaling
GO:0030334	regulation of cell migration
GO:0042098	T cell proliferation
GO:0042119	neutrophil activation
GO:0070098	chemokine-mediated signaling pathway

Cellular Component

GO:0005911	cell-cell junction
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0030426	growth cone

Protein Structure and Domains

PDB ID

MGI:109563

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001277 CXC chemokine receptor 4
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR022726 CXC chemokine receptor 4 N-terminal domain

PFAM

PF00001
PF10320
PF12109

PRINTS

PR00237
PR00645

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

E9Q2D4

UniProt Splice Variant

Entrez Gene

12767

UniGene

Mm.1401

RefSeq

MGI ID

MGI Symbol

Cxcr4

OMIM

CCDS

HPRD

IMGT

EMBL

AC161170 EF101560

GenPept

ABK96809