InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mus81

Summary

InnateDB Protein

IDBP-535575.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mus81

Protein Name

MUS81 endonuclease homolog (yeast)

Synonyms

1200008A18Rik; AI182501; AW045863;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000114895

InnateDB Gene

IDBG-131880 (Mus81)

Protein Structure

UniProt Annotation

Function

Interacts with EME1 and EME2 to form a DNA structure- specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks. {ECO:0000269PubMed:14609959, ECO:0000269PubMed:15205536, ECO:0000269PubMed:16107704}.

Subcellular Localization

Nucleus, nucleolus. Note=Recruited to foci of DNA damage in S-phase cells. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003824	catalytic activity
GO:0004518	nuclease activity
GO:0005515	protein binding
GO:0046872	metal ion binding
GO:0048257	3'-flap endonuclease activity

Biological Process

GO:0000737	DNA catabolic process, endonucleolytic
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0072429	response to intra-S DNA damage checkpoint signaling