InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tnfaip3

Summary

InnateDB Protein

IDBP-535629.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tnfaip3

Protein Name

tumor necrosis factor, alpha-induced protein 3

Synonyms

A20; Tnfip3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000120627

InnateDB Gene

IDBG-135792 (Tnfaip3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 67 interaction(s) predicted by orthology.

Experimentally validated
Total	38 [view]
Protein-Protein	30 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	67 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0004221	ubiquitin thiolesterase activity
GO:0004842	ubiquitin-protein transferase activity
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0043130	ubiquitin binding
GO:0043621	protein self-association

Biological Process

GO:0031397	negative regulation of protein ubiquitination
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032703	negative regulation of interleukin-2 production
GO:0034140	negative regulation of toll-like receptor 3 signaling pathway
GO:0035871	protein K11-linked deubiquitination
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0045732	positive regulation of protein catabolic process
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0070536	protein K63-linked deubiquitination
GO:0070936	protein K48-linked ubiquitination
GO:0071108	protein K48-linked deubiquitination
GO:0072573	tolerance induction to lipopolysaccharide
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000349	negative regulation of CD40 signaling pathway
GO:2000352	negative regulation of endothelial cell apoptotic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome

Protein Structure and Domains

PDB ID

MGI:1196377

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

D3YXE1

UniProt Splice Variant

Entrez Gene

21929

UniGene

Mm.472346

RefSeq

MGI ID

MGI Symbol

Tnfaip3

OMIM

CCDS

HPRD

IMGT

EMBL

AC102657

GenPept