InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tra2b

Summary

InnateDB Protein

IDBP-535705.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tra2b

Protein Name

transformer 2 beta homolog (Drosophila)

Synonyms

5730405G21Rik; D16Ertd266e; Sfrs10; SIG-41; Silg41; TRA2beta;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000123782

InnateDB Gene

IDBG-148073 (Tra2b)

Protein Structure

UniProt Annotation

Function

Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. Highly expressed in uterus and brain. {ECO:0000269PubMed:8674539}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 58 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	58 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003729	mRNA binding

Biological Process

GO:0000381	regulation of alternative mRNA splicing, via spliceosome
GO:0000398	mRNA splicing, via spliceosome
GO:0048026	positive regulation of mRNA splicing, via spliceosome

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:106016

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P62996

PhosphoSite

PhosphoSite-P62996

TrEMBL

UniProt Splice Variant

Entrez Gene

20462

UniGene

Mm.431896

RefSeq

MGI ID

MGI Symbol

Tra2b

OMIM

CCDS

HPRD

IMGT

EMBL

AK049573 AK077418 AK080378 BC061177 X80232

GenPept

AAH61177 BAC33819 BAC36791 BAC37898 CAA56518