Version 5.4
Mus musculus Protein: Fgd4
Summary
InnateDB Protein IDBP-535742.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fgd4
Protein Name FYVE, RhoGEF and PH domain containing 4
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000125649
InnateDB Gene IDBG-137062 (Fgd4)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005089 Rho guanyl-nucleotide exchange factor activity
Biological Process
GO:0007257 activation of JUN kinase activity
GO:0030032 lamellipodium assembly
GO:0030035 microspike assembly
GO:0032319 regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
Cellular Component
GO:0015629 actin cytoskeleton
GO:0030027 lamellipodium
GO:0030175 filopodium
Protein Structure and Domains
PDB ID MGI:2183747
InterPro IPR000219 Dbl homology (DH) domain
PFAM PF00621
PRINTS
PIRSF
SMART SM00325
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E0CZ69
UniProt Splice Variant
Entrez Gene 224014
UniGene Mm.405784
RefSeq XP_006522093
MGI ID
MGI Symbol Fgd4
OMIM
CCDS
HPRD
IMGT
EMBL AC169505 CT476831 CT573014
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca