InnateDB Protein
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IDBP-535793.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Fhit
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Protein Name
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fragile histidine triad gene
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Synonyms
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AW045638; Fra14A2;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000124073
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InnateDB Gene
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IDBG-132104 (Fhit)
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Protein Structure
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Function |
Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'- adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity (By similarity). Functions as tumor suppressor. {ECO:0000250, ECO:0000269PubMed:10758156, ECO:0000269PubMed:11517343}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:9699672}.
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Disease Associations |
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Tissue Specificity |
Expressed in heart, brain, lung and skeletal muscle. Particularly strong expression in liver, testis and kidney, where it is confined to the tubular epithelium. {ECO:0000269PubMed:9671749, ECO:0000269PubMed:9699672}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
13 [view]
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Molecular Function |
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Biological Process |
GO:0006163
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purine nucleotide metabolic process
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GO:0006260
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DNA replication
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GO:0006351
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transcription, DNA-templated
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0009117
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nucleotide metabolic process
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GO:0032435
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negative regulation of proteasomal ubiquitin-dependent protein catabolic process
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GO:0072332
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intrinsic apoptotic signaling pathway by p53 class mediator
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Cellular Component |
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PDB ID |
MGI:1277947
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InterPro |
IPR001310
Histidine triad (HIT) protein
IPR011146
HIT-like domain
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PFAM |
PF01230
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PRINTS |
PR00332
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O89106
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PhosphoSite |
PhosphoSite-O89106
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TrEMBL |
Q91Y56
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UniProt Splice Variant |
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Entrez Gene |
14198
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UniGene |
Mm.441926
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RefSeq |
NP_034340
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MGI ID |
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MGI Symbol |
Fhit
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OMIM |
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CCDS |
CCDS49400
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HPRD |
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IMGT |
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EMBL |
AC102431
AC105071
AC154197
AC154360
AC154570
AC154708
AC154776
AC158979
AC159306
AF047699
AF055573
AH006186
AH010680
AH013372
AL589696
BC012662
CT485999
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GenPept |
AAC23967
AAC24117
AAC24566
AAH12662
AAK43475
AAR17701
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