InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ppp3cb

Summary

InnateDB Protein

IDBP-535799.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppp3cb

Protein Name

protein phosphatase 3, catalytic subunit, beta isoform

Synonyms

1110063J16Rik; Calnb; Cnab; CnAbeta;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000125722

InnateDB Gene

IDBG-135249 (Ppp3cb)

Protein Structure

UniProt Annotation

Function

Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.

Subcellular Localization

Disease Associations

Tissue Specificity

Two isoforms in Ehrlich ascites tumor (EAT) is demonstrated by polymerase chain reaction specific primers to the catalytic and calmodulin-binding domain, respectively. Isoform 1 is of medium abundance in EAT cells. {ECO:0000269PubMed:1328240}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004722	protein serine/threonine phosphatase activity
GO:0004723	calcium-dependent protein serine/threonine phosphatase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0008144	drug binding
GO:0016787	hydrolase activity
GO:0019899	enzyme binding
GO:0030346	protein phosphatase 2B binding
GO:0033192	calmodulin-dependent protein phosphatase activity
GO:0046983	protein dimerization activity

Biological Process

GO:0001915	negative regulation of T cell mediated cytotoxicity
GO:0006468	protein phosphorylation
GO:0006470	protein dephosphorylation
GO:0007507	heart development
GO:0010468	regulation of gene expression
GO:0017156	calcium ion-dependent exocytosis
GO:0030217	T cell differentiation
GO:0031987	locomotion involved in locomotory behavior
GO:0034097	response to cytokine
GO:0035176	social behavior
GO:0035690	cellular response to drug
GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0043029	T cell homeostasis
GO:0050796	regulation of insulin secretion

Cellular Component

GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005955	calcineurin complex

Protein Structure and Domains

PDB ID

MGI:107163

InterPro

IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
IPR029052 Metallo-dependent phosphatase-like

PFAM

PF00149

PRINTS

PR00114

PIRSF

SMART

SM00156

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt