Version 5.4
| Mus musculus Protein: Plekhg2 | |||||||
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| Summary | |||||||
| InnateDB Protein | IDBP-535808.4 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | Plekhg2 | ||||||
| Protein Name | pleckstrin homology domain containing, family G (with RhoGef domain) member 2 | ||||||
| Synonyms | AI194308; Clg; Cslg; | ||||||
| Species | Mus musculus | ||||||
| Ensembl Protein | ENSMUSP00000115651 | ||||||
| InnateDB Gene | IDBG-163140 (Plekhg2) | ||||||
| Protein Structure |
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| UniProt Annotation | |||||||
| Function | May be a transforming oncogene with exchange activity for CDC42. May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (By similarity). {ECO:0000250}. | ||||||
| Subcellular Localization | |||||||
| Disease Associations | |||||||
| Tissue Specificity | Expressed in thymus, skeletal muscle, lung, testis, uterus, pancreas and heart and also expressed during embryogenesis. {ECO:0000269PubMed:11839748}. | ||||||
| Comments | |||||||
| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||
| PDB ID | MGI:2141874 | ||||||
| InterPro |
IPR000219
Dbl homology (DH) domain IPR001849 Pleckstrin homology domain |
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| PFAM |
PF00621
PF00169 |
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| PRINTS | |||||||
| PIRSF | |||||||
| SMART |
SM00325
SM00233 |
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| TIGRFAMs | |||||||
| Post-translational Modifications | |||||||
| Modification | |||||||
| Cross-References | |||||||
| SwissProt | Q6KAU7 | ||||||
| PhosphoSite | PhosphoSite-Q6KAU7 | ||||||
| TrEMBL | |||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | 101497 | ||||||
| UniGene | Mm.235700 | ||||||
| RefSeq | |||||||
| MGI ID | |||||||
| MGI Symbol | Plekhg2 | ||||||
| OMIM | |||||||
| CCDS | |||||||
| HPRD | |||||||
| IMGT | |||||||
| EMBL | AF465238 AK131110 AK144152 BC025625 BC052436 BC056971 | ||||||
| GenPept | AAH25625 AAH52436 AAH56971 AAL93134 BAD21360 BAE25733 | ||||||