Mus musculus Protein: Pou2f1
Summary
InnateDB Protein IDBP-535816.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pou2f1
Protein Name POU domain, class 2, transcription factor 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000125371
InnateDB Gene IDBG-202815 (Pou2f1)
Protein Structure
UniProt Annotation
Function Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity Ubiquitously expressed. However, isoforms 4 and 5 are only expressed in lymphocytes. {ECO:0000269PubMed:10023087, ECO:0000269PubMed:11683265, ECO:0000269PubMed:14729276, ECO:0000269PubMed:7711063}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 52 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 13 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 52 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
Protein Structure and Domains
PDB ID MGI:101898
InterPro IPR000327 POU-specific
IPR000972 Octamer-binding transcription factor
IPR001356 Homeobox domain
IPR009057 Homeodomain-like
IPR010982 Lambda repressor-like, DNA-binding domain
IPR013847 POU domain
PFAM PF00157
PF00046
PF13413
PRINTS PR00029
PR00028
PIRSF
SMART SM00352
SM00389
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-P25425
TrEMBL
UniProt Splice Variant
Entrez Gene 18986
UniGene Mm.448785
RefSeq
MGI ID
MGI Symbol Pou2f1
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept