InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GRK1

Summary

InnateDB Protein

IDBP-53588.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRK1

Protein Name

G protein-coupled receptor kinase 1

Synonyms

GPRK1; RHOK; RK;

Species

Homo sapiens

Ensembl Protein

ENSP00000334876

InnateDB Gene

IDBG-53586 (GRK1)

Protein Structure

UniProt Annotation

Function

Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination. {ECO:0000269PubMed:15946941}.

Subcellular Localization

Membrane; Lipid-anchor.

Disease Associations

Night blindness, congenital stationary, Oguchi type 2 (CSNBO2) [MIM:613411]: A non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and myopia. Congenital stationary night blindness Oguchi type is associated with fundus discoloration and abnormally slow dark adaptation. {ECO:0000269PubMed:17070587, ECO:0000269PubMed:9020843}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Retinal-specific. Expressed in rods and cones cells. {ECO:0000269PubMed:11717351}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004703	G-protein coupled receptor kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0050254	rhodopsin kinase activity

Biological Process

GO:0006468	protein phosphorylation
GO:0007601	visual perception
GO:0007603	phototransduction, visible light
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0008594	photoreceptor cell morphogenesis
GO:0009416	response to light stimulus
GO:0016056	rhodopsin mediated signaling pathway
GO:0022400	regulation of rhodopsin mediated signaling pathway
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0042327	positive regulation of phosphorylation
GO:0043066	negative regulation of apoptotic process
GO:0046777	protein autophosphorylation
GO:0060060	post-embryonic retina morphogenesis in camera-type eye

Cellular Component

GO:0097381

photoreceptor disc membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000239 GPCR kinase
IPR000342 Regulator of G protein signalling domain
IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR016137 Regulator of G protein signalling superfamily
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00615
PF00069
PF07714

PRINTS

PR00717
PR01301
PR00109

PIRSF

SMART

SM00133
SM00220
SM00315
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt