InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GRK1

Summary

InnateDB Gene

IDBG-53586.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRK1

Gene Name

G protein-coupled receptor kinase 1

Synonyms

GPRK1; RHOK; RK

Species

Homo sapiens

Ensembl Gene

ENSG00000185974

Encoded Proteins

IDBP-53588

G protein-coupled receptor kinase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:113667155-113737735

Strand

Forward strand

Band

q34

Transcripts

ENST00000335678	ENSP00000334876
ENST00000545304
ENST00000606140

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004703	G-protein coupled receptor kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0050254	rhodopsin kinase activity

Biological Process

GO:0006468	protein phosphorylation
GO:0007601	visual perception
GO:0007603	phototransduction, visible light
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0008594	photoreceptor cell morphogenesis
GO:0009416	response to light stimulus
GO:0016056	rhodopsin mediated signaling pathway
GO:0022400	regulation of rhodopsin mediated signaling pathway
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0042327	positive regulation of phosphorylation
GO:0043066	negative regulation of apoptotic process
GO:0046777	protein autophosphorylation
GO:0060060	post-embryonic retina morphogenesis in camera-type eye

Cellular Component

GO:0097381

photoreceptor disc membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000031450

View Gene Order

ENSBTAG00000019963

Not yet available

Pathways

NETPATH

REACTOME

REACT_111102

Signal Transduction pathway

REACT_160102

Diseases associated with visual transduction pathway

REACT_160125

Visual phototransduction pathway

REACT_163722

The phototransduction cascade pathway

REACT_163919

Inactivation, recovery and regulation of the phototransduction cascade pathway

REACT_116125

Disease pathway

KEGG

hsa04144

Endocytosis pathway

hsa04062

Chemokine signaling pathway pathway

hsa04744

Phototransduction pathway

INOH

PID NCI

cone_pathway

Visual signal transduction: Cones

rhodopsin_pathway

Visual signal transduction: Rods

Cross-References

SwissProt

Q15835

TrEMBL

Q71VB6

UniProt Splice Variant

Entrez Gene

6011

UniGene

Hs.103501 Hs.739350

RefSeq

NM_002929

HUGO

HGNC:10013

OMIM

180381

CCDS

HPRD

IMGT

EMBL

AC187648 AF019764 AF019765 AK289912 L77496 L77497 L77498 L77499 L77500 L77501 L77502 L77503 U63973

GenPept

AAB05929 AAC97161 AAG50439 AAT00534 BAF82601

RNA Seq Atlas

6011