Version 5.4
Mus musculus Protein: Lrp8
Summary
InnateDB Protein IDBP-535881.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lrp8
Protein Name low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
Synonyms 4932703M08Rik; AA921429; AI848122; ApoER2; Lr8b;
Species Mus musculus
Ensembl Protein ENSMUSP00000115854
InnateDB Gene IDBG-171850 (Lrp8)
Protein Structure
UniProt Annotation
Function Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor. {ECO:0000269PubMed:12695510}.
Subcellular Localization Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Secreted. Note=Isoforms that contain the exon coding for a furin-type cleavage site are proteolytically processed, leading to a secreted receptor fragment.
Disease Associations
Tissue Specificity Expressed in neurons throughout the brain, with strong expression in pyramidal neurons of the hippocampus, granule cells of the dentate gyrus, cortical neurons and Purkinje cells of the cerebellum. Also expressed in the epithelium of the choroid plexus and of the blood vessels (apical expression), as well as in the epididymis. {ECO:0000269PubMed:10827199}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 9 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0005041 low-density lipoprotein receptor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0034185 apolipoprotein binding
GO:0038025 reelin receptor activity
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006897 endocytosis
GO:0006898 receptor-mediated endocytosis
GO:0021517 ventral spinal cord development
GO:0021541 ammon gyrus development
GO:0021766 hippocampus development
GO:0021819 layer formation in cerebral cortex
GO:0032793 positive regulation of CREB transcription factor activity
GO:0038026 reelin-mediated signaling pathway
GO:0045860 positive regulation of protein kinase activity
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050804 regulation of synaptic transmission
GO:0061003 positive regulation of dendritic spine morphogenesis
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:1900006 positive regulation of dendrite development
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0043235 receptor complex
Protein Structure and Domains
PDB ID MGI:1340044
InterPro IPR000033 LDLR class B repeat
IPR000742 Epidermal growth factor-like domain
IPR001881 EGF-like calcium-binding domain
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
IPR009030 Insulin-like growth factor binding protein, N-terminal
PFAM PF00058
PF00008
PF07645
PF00057
PRINTS PR00261
PIRSF
SMART SM00135
SM00181
SM00179
SM00192
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q924X6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 16975
UniGene Mm.439353
RefSeq
MGI ID
MGI Symbol Lrp8
OMIM
CCDS
HPRD
IMGT
EMBL AJ312058 D85463
GenPept BAB46965 CAC38356

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca