InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Thnsl2

Summary

InnateDB Protein

IDBP-535909.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Thnsl2

Protein Name

threonine synthase-like 2 (bacterial)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000124423

InnateDB Gene

IDBG-155229 (Thnsl2)

Protein Structure

UniProt Annotation

Function

Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate. Also degrades O-phospho-homoserine (PHS), but this is not its physiological substrate. {ECO:0000269PubMed:17034760}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016829	lyase activity
GO:0030170	pyridoxal phosphate binding
GO:0070905	serine binding

Biological Process

GO:0009071	serine family amino acid catabolic process
GO:0016311	dephosphorylation
GO:0046360	2-oxobutyrate biosynthetic process

Cellular Component

GO:0005575

cellular_component

Protein Structure and Domains

PDB ID

MGI:3041254

InterPro

IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzymes superfamily
IPR004450 Threonine synthase-like

PFAM

PF00291

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q80W22

PhosphoSite

PhosphoSite-Q80W22

TrEMBL

UniProt Splice Variant

Entrez Gene

232078

UniGene

Mm.427276

RefSeq

NP_001029101

MGI ID

MGI Symbol

Thnsl2

OMIM

CCDS

CCDS20225

HPRD

IMGT

EMBL

AK165463 BC025604 BC051244

GenPept

AAH25604 AAH51244 BAE38200