InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Vezt

Summary

InnateDB Protein

IDBP-535952.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vezt

Protein Name

vezatin, adherens junctions transmembrane protein

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000121727

InnateDB Gene

IDBG-186394 (Vezt)

Protein Structure

UniProt Annotation

Function

Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. Required for morphogenesis of the preimplantation embryo, and for the implantation process. {ECO:0000269PubMed:16199027, ECO:0000269PubMed:17452094}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Cell junction, adherens junction. Nucleus. Cytoplasmic vesicle, secretory vesicle, acrosome.

Disease Associations

Tissue Specificity

Isoform 1, isoform 2 and isoform 3 are expressed in testis. In the seminiferous epithelium, present exclusively in the acrosome of spermatids (at protein level). {ECO:0000269PubMed:17379651}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017022	myosin binding

Biological Process

GO:0016337	single organismal cell-cell adhesion
GO:0043009	chordate embryonic development

Cellular Component

GO:0001669	acrosomal vesicle
GO:0002142	stereocilia ankle link complex
GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0005912	adherens junction
GO:0016021	integral component of membrane