InnateDB Protein
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IDBP-535966.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Stag3
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Protein Name
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stromal antigen 3
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Synonyms
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SA-2;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000125523
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InnateDB Gene
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IDBG-206116 (Stag3)
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Protein Structure
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Function |
Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis- specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00750, ECO:0000269PubMed:22346761}. Chromosome {ECO:0000269PubMed:22346761}. Chromosome, centromere {ECO:0000269PubMed:22346761}. Note=Associates with chromatin. In prophase I stage of meiosis, it is found along the axial elements of synaptonemal complexes. In late-pachytene-diplotene, the bulk of protein dissociates from the chromosome arms probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. It however remains chromatin associated at the centromeres up to metaphase I. During anaphase I, it probably dissociates from centromeres, allowing chromosomes segregation.
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Disease Associations |
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Tissue Specificity |
Testis specific.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
GO:0007065
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male meiosis sister chromatid cohesion
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GO:0007066
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female meiosis sister chromatid cohesion
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Cellular Component |
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PDB ID |
MGI:1355311
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InterPro |
IPR013721
STAG
IPR016024
Armadillo-type fold
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PFAM |
PF08514
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O70576
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PhosphoSite |
PhosphoSite-O70576
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TrEMBL |
Q3V170
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UniProt Splice Variant |
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Entrez Gene |
50878
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UniGene |
Mm.285609
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RefSeq |
XP_006504659
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MGI ID |
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MGI Symbol |
Stag3
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OMIM |
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CCDS |
CCDS39344
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HPRD |
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IMGT |
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EMBL |
AC157588
AC159257
AJ005678
AK132652
AK158240
BC139010
BC139011
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GenPept |
AAI39011
AAI39012
BAE21282
BAE34419
CAA06669
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