Version 5.4
Mus musculus Protein: H1foo
Summary
InnateDB Protein IDBP-535973.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol H1foo
Protein Name H1 histone family, member O, oocyte-specific
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000123797
InnateDB Gene IDBG-179926 (H1foo)
Protein Structure
UniProt Annotation
Function May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling. {ECO:0000269PubMed:11171391, ECO:0000269PubMed:14729479, ECO:0000269PubMed:15371275, ECO:0000269PubMed:17519519}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus. Chromosome. Note=In the germinal vesicle oocyte, localizes to the condensed chromosomes. In the 1-cell embryo found in condensed maternal metaphase chromatin but not in the sperm head. Following second polar body extrusion, detected in the swollen sperm head as well as in the second polar body. Reduced expression in the nucleus in 2-cell embryo is seen as compared to 1-cell embryo.
Disease Associations
Tissue Specificity Oocyte-specific. {ECO:0000269PubMed:11171391, ECO:0000269PubMed:15371275}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0031492 nucleosomal DNA binding
Biological Process
GO:0006334 nucleosome assembly
GO:0007126 meiotic nuclear division
GO:0016584 nucleosome positioning
GO:0044030 regulation of DNA methylation
GO:2000737 negative regulation of stem cell differentiation
Cellular Component
GO:0000786 nucleosome
GO:0001674 female germ cell nucleus
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:2176207
InterPro IPR005818 Linker histone H1/H5, domain H15
PFAM PF00538
PRINTS
PIRSF
SMART SM00526
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8VIK3
PhosphoSite PhosphoSite-Q8VIK3
TrEMBL
UniProt Splice Variant
Entrez Gene 171506
UniGene Mm.21899
RefSeq XP_006505741
MGI ID
MGI Symbol H1foo
OMIM
CCDS
HPRD
IMGT
EMBL AK135944 AK162137 AY007195 BC137916 CH466523
GenPept AAG01890 AAI37917 BAE22736 BAE36747 EDK99547

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca