InnateDB Protein
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IDBP-536023.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Opa1
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Protein Name
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optic atrophy 1 homolog (human)
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Synonyms
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1200011N24Rik; AI225888; AI847218; lilr3; mKIAA0567;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000123880
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InnateDB Gene
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IDBG-151468 (Opa1)
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Protein Structure
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Function |
Dynamin-related GTPase required for mitochondrial fusion and regulation of apoptosis. May form a diffusion barrier for proteins stored in mitochondrial cristae. Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space.Dynamin-like 120 kDa protein, form S1: Inactive form produced by cleavage at S1 position by OMA1 following stress conditions that induce loss of mitochondrial membrane potential, leading to negative regulation of mitochondrial fusion.
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Subcellular Localization |
Mitochondrion inner membrane {ECO:0000269PubMed:16839884}; Single-pass membrane protein {ECO:0000269PubMed:16839884}. Mitochondrion intermembrane space {ECO:0000269PubMed:16839884}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
9
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
22 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1921393
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InterPro |
IPR001401
Dynamin, GTPase domain
IPR022812
Dynamin superfamily
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF00350
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PRINTS |
PR00195
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PIRSF |
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SMART |
SM00053
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TIGRFAMs |
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Modification |
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SwissProt |
P58281
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PhosphoSite |
PhosphoSite-P58281
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TrEMBL |
Q8BK99
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UniProt Splice Variant |
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Entrez Gene |
74143
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UniGene |
Mm.421980
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RefSeq |
XP_006522717
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MGI ID |
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MGI Symbol |
Opa1
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AB044138
AK029157
AK038446
AK044657
AK050383
AK053861
AK145620
BC025160
BC138665
BC145959
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GenPept |
AAH25160
AAI38666
AAI45960
BAB59000
BAC26331
BAC30002
BAC32021
BAC34224
BAC35561
BAE26544
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