InnateDB Protein
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IDBP-536025.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Btf3
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Protein Name
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basic transcription factor 3
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000118093
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InnateDB Gene
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IDBG-175833 (Btf3)
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Protein Structure
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Function |
When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus. Note=The heterodimer with NACA is cytoplasmic. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
17 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1202875
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InterPro |
IPR002715
Nascent polypeptide-associated complex NAC domain
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PFAM |
PF01849
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q64152
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PhosphoSite |
PhosphoSite-Q64152
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TrEMBL |
Q3UJR8
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UniProt Splice Variant |
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Entrez Gene |
218490
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UniGene |
Mm.390183
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RefSeq |
NP_001164011
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MGI ID |
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MGI Symbol |
Btf3
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OMIM |
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CCDS |
CCDS49340
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HPRD |
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IMGT |
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EMBL |
AK139664
AK146332
AK147171
BC008233
BC064010
BC080837
CH466567
S79537
S79538
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GenPept |
AAH08233
AAH64010
AAH80837
BAE24097
BAE27087
BAE27735
EDL00853
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