InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Arap1

Summary

InnateDB Protein

IDBP-536029.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arap1

Protein Name

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

Synonyms

2410002L19Rik; Centd2; mKIAA0782;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000121431

InnateDB Gene

IDBG-201910 (Arap1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005100	Rho GTPase activator activity
GO:0005515	protein binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008060	ARF GTPase activator activity
GO:0031702	type 1 angiotensin receptor binding

Biological Process

GO:0001921	positive regulation of receptor recycling
GO:0008360	regulation of cell shape
GO:0043089	positive regulation of Cdc42 GTPase activity
GO:0051270	regulation of cellular component movement
GO:0051491	positive regulation of filopodium assembly
GO:0051497	negative regulation of stress fiber assembly

Cellular Component

GO:0005802	trans-Golgi network
GO:0005886	plasma membrane
GO:0031410	cytoplasmic vesicle

Protein Structure and Domains

PDB ID

MGI:1916960

InterPro

IPR001660 Sterile alpha motif domain
IPR011510 Sterile alpha motif, type 2
IPR013761 Sterile alpha motif/pointed domain
IPR021129 Sterile alpha motif, type 1

PFAM

PF07647
PF00536

PRINTS

PIRSF

SMART

SM00454

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite