Mus musculus Protein: Atxn7l3
Summary
InnateDB Protein IDBP-536058.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Atxn7l3
Protein Name ataxin 7-like 3
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000122610
InnateDB Gene IDBG-212566 (Atxn7l3)
Protein Structure
UniProt Annotation
Function Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex. {ECO:0000255HAMAP- Rule:MF_03047}.
Subcellular Localization Nucleus {ECO:0000255HAMAP-Rule:MF_03047}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Protein Structure and Domains
PDB ID MGI:3036270
InterPro IPR013243 SCA7 domain
IPR013246 SAGA complex, Sgf11 subunit
PFAM PF08313
PF08209
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-A2AWT3
TrEMBL Z4YN62
UniProt Splice Variant
Entrez Gene 217218
UniGene Mm.466283
RefSeq
MGI ID
MGI Symbol Atxn7l3
OMIM
CCDS
HPRD
IMGT
EMBL AL954730
GenPept