InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Aptx

Summary

InnateDB Protein

IDBP-536213.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aptx

Protein Name

aprataxin

Synonyms

2410016G21Rik; AA388047; FHA-HIT;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000124264

InnateDB Gene

IDBG-136241 (Aptx)

Protein Structure

UniProt Annotation

Function

DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non- ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'- monophosphoramidate (AMP-NH2) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity. {ECO:0000269PubMed:16964241}.

Subcellular Localization

Nucleus, nucleoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Upon genotoxic stress, colocalizes with XRCC1 at sites of DNA damage. Colocalizes with MDC1 at sites of DNA double-strand breaks. Interaction with NCL is required for nucleolar localization (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. Expressed in heart, liver, kidney, spleen, lung, muscle, brain stem, spinal cord, cerebellum and brain. {ECO:0000269PubMed:11586300}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003684	damaged DNA binding
GO:0003690	double-stranded DNA binding
GO:0003725	double-stranded RNA binding
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0008967	phosphoglycolate phosphatase activity
GO:0033699	DNA 5'-adenosine monophosphate hydrolase activity
GO:0046403	polynucleotide 3'-phosphatase activity
GO:0046872	metal ion binding
GO:0047485	protein N-terminus binding
GO:0051219	phosphoprotein binding

Biological Process

GO:0000012	single strand break repair
GO:0000738	DNA catabolic process, exonucleolytic
GO:0006266	DNA ligation
GO:0006302	double-strand break repair
GO:0006974	cellular response to DNA damage stimulus
GO:0016311	dephosphorylation
GO:0031647	regulation of protein stability
GO:0042542	response to hydrogen peroxide
GO:0098506	polynucleotide 3' dephosphorylation